206 Successful Islet Outcomes Using Australia Wide Donors: A National Centre Experience
Monday November 16, 2015 from 07:00 to 08:00
Room 110

Wayne J Hawthorne, Australia


National Pancreas and Islet Transplant Laboratories

Westmead Hospital


Successful Islet Outcomes Using Australia Wide Donors: A National Centre Experience

Wayne Hawthorne1,2,3, Sussan Davies1, Lindy Williams1, Patricia Anderson1, Tina Patel1, Philip O'Connell1,2.

1The Centre for Transplant & Renal Research, Westmead Millennium Institute, Westmead, Australia; 2Westmead Clinical School, Sydney Medical School, University of Sydney, Westmead, Australia; 3Department of Surgery, Westmead Hospital, Westmead, Australia

Travel time and hence cold ischemia time can adversely affect outcomes of islet isolation.
The aim of this study was to compare the isolation and transplant outcomes of donor pancreata according to the distance retreived from the islet isolation facility. Principally those within a 50 km radius of the centre were compared with those from regional areas within the state and those from interstate donors within Australia up to 4,000km away.
Methods: Organ donors were categorised according to distance from National Pancreas Transplant Unit Westmead (NPTU). Donor characteristics were analysed statistically against islet isolation outcomes. These were; age, BMI, cause and mechanism of death, days in ICU, gender, inotrope and steroid use, cold ischemia time (CIT) and retrieval surgical team.
Results: Between March 2007 and June 2014, 143 islet isolations were performed at our centre.  32-donor pancreata were local area, and 111 non-local regions. Mean distance from the isolation facility was 746.77 km. Mean pancreas CIT was 415.47 ± 146.60 minutes and was significantly different between local and non-local groups (248.1 vs. 463.7 minutes, p<0.01). Mean age of donors was 46.74 years, mean BMI was 28.23, sex ratio was 45:55 F:M and mean time in ICU was 2.87 days. There was no significant difference between local and non-local for these characteristics. The mean CIT resulting in islet transplantation was 376.2 ± 137.2 min and longest CIT resulting in transplantation was 676 minutes.  There was no significant difference in islet isolation outcomes between local and non-local donors for characteristics other than CIT. There was also no significant effect of distance from the isolation facility on positive islet transplant outcomes (C-peptide >0.2 at 1 month post-transplant).
Conclusions: Distance from the isolation centre did not impact on isolation or transplant outcomes supporting the ongoing nationwide use of shipping pancreata for islet isolation and transplantation in Australia.

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