Chairman and Professor
University of Maryland
Long term outcome of 83 SPLK transplants at a single center
Eric Siskind1, Eugene Schweitzer1, Lauren Pettinato1, Stephen Bartlett1.
1Transplant Surgery, University of Maryland Medical Center, Baltimore, MD, United States
Introduction: Simultaneous deceased donor pancreas and living donor kidney (SPLK) transplant is a treatment option for uremic diabetics with live kidney donors willing to be available “on-call” while the recipient waits for the pancreas. While short term results of smaller series of SPLK transplants are reported to be comparable to stan dard SPK transplants (Perosa, 2011, Farney, 2000), there are no published data on long term outcomes.
Methods: Data was obtained from the UNOS database regarding all pancreas transplants performed between 1998 and 2005 at the University of Maryland (n=396). Patients receiving an SPLK transplant (n=83) were compared to those receiving adeceased donor pancreas–kidney (SPK) transplant (n=106), pancreas after kidney (PAK) transplant (n=118), and pancreas transplant alone (PTA) (n=89). Donor and recipient variables were compared with Mann-Whitney and chi-square tests. Kaplan-meier survival curveswere plotted for death-censored graft survival rates, and compared with log-rank tests.
Results: Long term kidney and pancreas graft survivals are shown in the tables and charts. The survival differences between the groups were not statistically significant; however, there was a trend towards improved kidney allograft survival in SPLK recipients. The median wait time foran SPLK transplant was significantly shorter than for an SPK (96 vs 297 days, p<0.001).
Conclusion: Use of SPLK transplant instead of SPK can markedly reduce the wait time for pancreas-kidney recipients, expand the global kidney donor pool, and provide for improved kidney allograft graft survival.
 Farney AC, Cho E, Schweitzer EJ, Dunkin B, Philosophe B, Colonna J, Jacobs S, Jarrell B, Flowers JL, Bartlett ST: Simultaneous cadaver pancreas living-donor kidney transplantation: a new approach for the type I diabetic uremic patient. Ann Surg 2000;232:69
 Perosa M, Crescentini F, Noujaim H, Mota LT, Branez JR, Ianhez LE, Ferreira G, de Oliveira RA, Genzini T. Over 500 pancreas transplants by a single team in Sao Paulo, Brazil. Clin Transplant. 2011 In press
13:00 - 16:15
|Pancreas Transplantation: Global Trends in Pancreas Transplantation – challenges and opportunities||Challenges: Risk aversion, Reimbursement and other issues||Room 110|
11:00 - 12:30
|Progress and clinical outcomes in pancreas transplantation||Long term outcome of 83 SPLK transplants at a single center||Room 110|