Konkuk University Hospital
The three-years experiences of kidney and heart xenotransplantation of pig to non-human primate, which is first trials in Korea
Ik Jin Yun1, Hyeon Keun Chee2, Joon Seok Kim2, Jeong Hwan Park3, Kyung Sik Park1, Hyeon Sook Yang3, Seon Won Lee1, Won Jung Yun1, Ka Hee Cho4, Wan Je Park4, Seon A Ock5, Seong Soo Hwang5, Keon Bong Oh5, Jae Seok Yang6, Kyu Hyeon Han6, Curie Ahn6.
1Surgery, Konkuk University Hospital, Seoul, Korea; 2Cardiovascular Surgery, Konkuk University Hospital, Seoul, Korea; 3Internal Medicine, Konkuk University Hospital, Seoul, Korea; 4Orient Genia Inc., Seoul, Korea; 5National Institute of Animal Science, Jeonjoo, Korea; 6Internal Medicine, Seoul National University Hospital, Seoul, Korea
Absolute shortage of donor comparing with want-to-transplantation patient is unsolved problem now, and only possible solution might be xenotransplantation. Before clinical trial, preclinical study using non-human primate should be done and many developed countries have done various solid organ experiments actively and the results are improving. In Korea, GalTKO pig was developed already, but solid organ xenotransplantation studies couldn’t be initiated. Islet cell and cornea has been tried, but solid organ transplantation team had never been organized with financial, technical and circumstantial problems. From Nov. 2011, our team has initiated heart and kidney first in Korea. We present this initiating 3 years results.
From 2011, we have received the governmental fund and established experimental settings for the pig to monkey kidney and heart xenotransplantation. Cynomolgus monkey is used as recipients. We use the immunosuppressants of CD154 ab, rituximab, ATG, Tacrolimus, MMF and steroid.
In 2011, only one case of kidney xenotransplantation was tried and the recipient had been expired on POD1 due to bleeding. From 2012 to 2014, 16 cases of heart and 5 cases of kidney xenotransplantation have been done. Almost every cases of early death before 3 days is due to technical failure, bleeding. However, even these cases do not show any sign of the hyper-acute rejection and anti-GalT antibody. The longest survival of kidney and heart is 25 and 45 days for each. This survival results are relatively poor yet, but longest 3 cases (45, 35, 24 days) of survival is recent cases and so results are improving.
Although solid organ xenotransplantation in Korea is just beginning and we are only team with insufficient resources and results, we expect the continuing experiments and studies to make comparative good results and contribute the development of solid organ xenotransplantation.
15:30 - 17:00
|Solid Organ Xenotransplantation (1)||The three-years experiences of kidney and heart xenotransplantation of pig to non-human primate, which is first trials in Korea||Room 109|