442 3D Printing Scaffolds Containing Living Cells
Tuesday November 17, 2015 from 09:00 to 10:30
Plenary Room 1

Gordon Wallace, Australia

University of Wollongong Australia

ARC Centre of Excellence in Electromaterials Science (ACES)


3D Scaffolds Containing Living Cells

Gordon Wallace1.

1ARC Centre of Excellence for Electromaterials Science / Intelligent Polymer Research Institute, University of Wollongong, Wollongong, Australia

The ability to strategically arrange living cells within a 3D construct is enabling fundamental experimental insights not available to us until recently.
The advent of 3D Bioprinting www.bioprintingebook.com has enabled us to create cytocompatible structures with tunable mechanical properties. Natural occurring polymers such as chitosan, alginate or gellan gum provide an appropriate chemical environment and the mechanical properties can be tuned by varying the nature as well as the degree of crosslinking. Such polymer structures can also serve as a depot for strategically distributed bioactive molecules such as drugs or growth factors. Some of these materials even display useful rheological properties that enable stabilisation of living cells as dispersers in inks and protection of these cells during the printing process.
Advances in this field are not only related to material developments and ink formulations but also depend critically on advances in printing hardware. Here we illustrate how the development of novel print heads (coaxial, asymmetric, side by side) and ink transfer mechanisms has enabled the realisation of complex cell containing arrangements.
As we build a body of knowledge around the creation of 3D biopolymer structures and the behaviour of cells within them this will undoubtedly create opportunities for their use as cell transplantation vehicles.

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